Our latest Publication in Neuroimage, October 2015
functional Ultrasound imaging becomes fully transcranial and non invasive when combined with Ultrasound contrast agents
Our team in collaboration with Dr. Zsolt Lenkei and Dr. Sophie Pezet from the Laboratory of Brain Plasticity at ESPCI, has recently published a new article in NeuroImage showing how fUltrasound has become a non-invasive imaging technique able to detect sensory activations in large rodents (rats) through the skull.
These results prove that by combining the sensitivity of ultrafast Doppler imaging with microbubbles ultrasound contrast agents (compensating for the bone attenuation of the ultrasonic waves), stimuli-induced changes in the cerebral blood volume can be evaluated transcranially deep within the rat cortex. Such microbubbles are typically 3 µm lipid shells, CE marked for clinical use. Such findings are extremely promising as not only they facilitate non-invasive longitudinal functional studies in rodents, but mainly they pave the way for the adoption of highly resolved fUS approaches for the adult human brain in clinics.
“Microbubble-aided transcranial fUS imaging has helped overcome one of the most important bony structure present in the body, while preserving high spatiotemporal resolution for functional Ultrasound of brain activity. It paves the way to transcranial fUltrasound imaging on human adults in a near future “, explains Claudia Errico, PhD student at the Langevin Institute – Wave Physics for Medicine.
Indeed, such transcranial fUS approach is probing boundaries between the high spatiotemporal resolution necessary to image the brain activation and the penetration of ultrasound through the skull.
For more information, see :
Transcranial Functional Ultrasound Imaging of the Brain using Microbubble-Enhanced Ultrasensitive Doppler.
Errico C, Osmanski BF, Pezet S, Couture O, Lenkei Z, Tanter M, Neuroimage. 2015 Sep 25. pii: S1053-8119(15)00852-6. doi: 10.1016/j.neuroimage.2015.09.037. [Epub ahead of print]