• First clinical fUS imaging on adult patients published in Scientific Reports

Intraoperative functional ultrasound imaging of the human brain activity

SRimage

Marion Imbault, Dorian Chauvet, Jean-Luc Gennisson, Laurent Capelle, Mickael Tanter
Scientific Reports 7, Article number: 7304 (2017), doi:10.1038/s41598-017-06474-8

Together with neurosurgeons of La Pitié-Salpétrière hospital, our team has performed a world premiere: for the first time, neurofunctional ultrasound (fUS) imaging of cerebral activity was performed on adult patients undergoing a surgery to remove low-grade gliomas located in their brain. This type of surgical procedure is conventionally guided using electrocortical stimulation mapping (ESM) to remove the tumor while preserving essential functional areas. In our study, we used fUS imaging to record the brain activity during the surgery, while ESM served as a reference method.

We demonstrated that fUS was able to map the brain activation in deep cortical regions as a response to a task-related stimulus, with a good spatial discrimation of neighbouring functional areas. fUS imaging has a great potential for intraoperative guidance of tumor resections by imaging stimulus-based activation in real-time, with a high sensitivity and spatial resolution.

Intraoperative fUS imaging of "mouth-sensitive"-evoked brain activation in a human patient. The results show a good correlation between the cerebral blood flow (CBV) increase and the stimulus, as well as a good spatial localization of the activated area.

Intraoperative fUS imaging of “mouth-sensitive”-evoked brain activation in a human patient. The results show a good correlation between the cerebral blood flow (CBV) increase and the stimulus, as well as a good spatial localization of the activated area.

 

fUS_human

 

 

 

With this first proof of concept publication in Scientific reports, Ultrasound becomes a new clinical neuroimaging modality. See the full-text published in Scientific Report: https://www.nature.com/articles/s41598-017-06474-8